Alopecia em pacientes anticoagulados
Alopecia in anticoagulated patients
Marcos Arêas Marques; Carmen Lucia Lascasas Porto; Ana Letícia de Matos Milhomens; Juliana de Miranda Vieira; Claudia Carvalho Alcântara Gomes; Ana Thereza Cavalcanti Rocha; Cíntia da Silva Miller
Resumo
Palavras-chave
Abstract
Alopecia is a common complication of anticoagulant therapy that may have important psychological repercussions for patients, especially female patients, and can interfere with the decision to extend anticoagulation. This review aims to describe the mechanisms potentially involved in the genesis of alopecia during anticoagulant therapy, since these are not yet fully understood, and discusses the existing therapies for the most appropriate management.
Keywords
References
1 World Health Organization. VigiBase: the database of suspected adverse reaction reports. 2017 [citado 2017 mar 13].
2 Wang YY, Po HL. Enoxaparin-induced alopecia in patients with cerebral venous thrombosis. J Clin Pharm Ther. 2006;31(5):513-7.
3 Christopoulou EC, Filippatos TD, Elisaf MS. Non-haemorrhage-related adverse effects of rivaroxaban. Arch Med Sci Atheroscler Dis. 2017;2(2):108-12.
4 Chretien B, Besnard A, Sassier M, et al. Rivaroxaban-induced hair loss. Eur J Clin Pharmacol. 2015;71(11):1413-4.
5 Watras MM, Patel JP, Arya R. Traditional anticoagulants and hair loss: a role for direct oral anticoagulants? A review of the literature. Drugs Real World Outcomes. 2016;3(1):1-6.
6 Poquet Jornet JE, Palés Argullós A, Portis Espinosa MT. Acenocoumarol-induced alopecia: report of three cases. Farm Hosp. 2000;24(5):314-8.
7 Weyand AC, Shavit JA. Agent specific effects of anticoagulant induced alopecia. Res Pract Thromb Haemost. 2017;1(1):90-2.
8 Frishman WH, Brosnan BD, Grossman M, Dasgupta D, Sun DK. Adverse dermatologic effects of cardiovascular drug therapy: part II. Cardiol Rev. 2002;10(4):230-46.
9 Santos FC, Maffei FHA, Carvalho LR, et al. Complicações da terapia anticoagulante com warfarina em pacientes com doença vascular periférica: estudo de coorte prospectivo. J Vasc Bras. 2006;5(3):194-202.
10 Leong WA. Case studies in anticoagulation management. J Thromb Thrombolysis. 2008;25(1):78-84.
11 Gamonal S, Gamonal A. Tricologia. HU Rev. 1999;25(2):118-37.
12 Gelbricht V, Koehler C, Werth S, et al. Hair loss is a potential side effect of novel oral anticoagulants-findings from the Dresden noac registry. Blood. 2012;120(21):1173.
13 Thiedke CC. Alopecia in women. Am Fam Physician. 2003;67(5):1007-14. PMid:12643360.
14 Patel M, Harrison S, Sinclair R. Drugs and Hair Loss. Dermatol Clin. 2013;31(1):67-73.
15 Varothai S, Bergfeld WF. Androgenetic alopecia: an evidence-based treatment update. Am J Clin Dermatol. 2014;15(3):217-30.
16 Stoehr JR, Choi JN, Colavincenzo M, Vanderweil S. Off-label use of topical minoxidil in alopecia: a review. Am J Clin Dermatol. 2019;20(2):237-50.