Jornal Vascular Brasileiro
https://www.jvascbras.org/article/doi/10.1590/1677-5449.190150
Jornal Vascular Brasileiro
Review Article

Suplementação de vitamina D e seus análogos para tratamento de disfunção endotelial e doenças cardiovasculares

Supplementation with vitamin D and its analogs for treatment of endothelial dysfunction and cardiovascular disease

Felipe Esdras Lucas Cardoso; Leandro da Cruz Melgaço dos Santos; Adirlene Pontes de Oliveira Tenório; Matheus Rodrigues Lopes; Romero Henrique de Almeida Barbosa

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Resumo

Resumo: A vitamina D (1,25-dihidroxicolecalciferol) é um pró-hormônio que tem despertado a atenção de pesquisadores após estudos demonstrarem que seus efeitos não estão restritos ao metabolismo ósseo. Assim, a presente revisão sintetiza os achados mais recentes e discute a utilidade da prescrição de vitamina D e seus análogos no tratamento e prevenção de afecções cardiovasculares e disfunção endotelial. Este trabalho consiste em uma revisão narrativa da literatura feita a partir da seleção de artigos publicados no período de 2012 a 2019. Estudos demonstraram efeitos benéficos da vitamina D3 e seus análogos sobre a função endotelial; no entanto, tais resultados mostram-se controversos, visto que pesquisas com maior amostragem e duração não encontraram redução na morbimortalidade ou nos fatores de risco cardiovascular após o uso de tais substâncias. Frente ao estado atual da arte, não existe embasamento científico claro para suplementação de vitamina D ou seus análogos para tratamento de disfunção endotelial ou doenças cardiovasculares.

Palavras-chave

vitamina D, doenças cardiovasculares, endotélio, suplementos nutricionais

Abstract

Vitamin D (1,25-dihydroxycolecalciferol) is a prohormone that has attracted the interest of researchers since studies have shown that its effects are not restricted to bone metabolism. Thus, the present review summarizes the most recent findings and discusses the usefulness of prescribing vitamin D and its analogues for treatment and prevention of cardiovascular disorders and endothelial dysfunction. The paper constitutes a narrative review of the literature, selecting articles published from 2012 to 2019. Studies have shown that vitamin D3 and its analogues have beneficial effects on endothelial function, but these results are controversial, since research with larger samples and of longer duration found no reduction in morbidity and mortality or cardiovascular risk factors after use of these substances. Given the current state of the art, there is no clear scientific basis for supplementation with vitamin D or its analogues for treatment of endothelial dysfunction or cardiovascular disease.

Keywords

vitamin D; cardiovascular diseases; endothelium; dietary supplements

References

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Submitted date:
12/06/2019

Accepted date:
03/17/2020

5eff29000e8825641af8e224 jvb Articles

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