Oclusão arterial aguda após infusão inadvertida de sacarato de hidróxido férrico (Noripurum®) na artéria radial: relato de caso
Acute arterial occlusion following inadvertent infusion of ferric hydroxide sacarate (Noripurum®) into the radial artery: case report
Daniel César Magalhães Fernandes; Daniel Rassi Gusmao; Felipe Mendonça Oliveira e Souza; Juliano Ricardo Santana dos Santos; Beatriz Franco Fidalgo
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Abstract
Iron overload, whether acute or chronic, has been implicated in the pathogenesis of ischemic cardiovascular diseases. However, its effects on peripheral vascular function and thrombotic responses to endothelial injury remain incompletely elucidated. We present a case of inadvertent intra-arterial infusion of ferric hydroxide saccharate (Noripurum®), resulting in severe acute arterial occlusion, most likely secondary to diffuse endothelial injury. Despite prompt surgical intervention and adjunctive pharmacological therapy, the clinical outcome was unfavorable. Given the lack of similar reports in major scientific databases and the involvement of complex, yet poorly characterized, interactions between iron overload and endothelial dysfunction, this case contributes valuable insights into the vascular implications of parenteral iron administration.
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References
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Submitted date:
05/01/2025
Accepted date:
12/10/2025
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