Terapias regenerativas para feridas complexas do pé diabético: desafio terapêutico
Regenerative therapies for complex diabetic foot wounds: a therapeutic challenge
Vinicius Tadeu Ramos da Silva Grillo; Eduardo Aparecido Romio; Caíque Damasceno Sousa; Gabriel Gomes Ranite; William Rodrigues da Silva; Pedro Luciano Melluci Filho; Francisco José de Oliveira Filho; Matheus Bertanha
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Abstract
Diabetic foot ulcers are a leading cause of morbidity, hospitalization, and nontraumatic lower-extremity amputation in patients with diabetes mellitus. Effective management of these wounds requires a multidisciplinary approach and combined therapies addressing infection control, perfusion optimization, and stimulation of tissue regeneration. This case report describes a patient with a severe infected neuroischemic foot ulcer treated with a sequential integrated strategy: infrapatellar endovascular revascularization, targeted antibiotic therapy, serial debridement, negative pressure wound therapy, application of an ovine-derived extracellular matrix, and autologous grafting of adipose tissue-derived mesenchymal stem cells. The treatment resulted in complete wound healing and limb preservation, with no recurrence after 7 months of follow-up. This case highlights the potential role of advanced regenerative therapies in the management of complex, refractory diabetic foot wounds, expanding therapeutic perspectives in the care of patients with diabetic foot.
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Referências
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Submetido em:
21/04/2025
Aceito em:
14/01/2026
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