Jornal Vascular Brasileiro
https://www.jvascbras.org/article/doi/10.1590/1677-5449.210014
Jornal Vascular Brasileiro
Original Article

Morphohistological analysis of the prevalence and distribution of atheroma in the abdominal aorta and its branches: a cadaveric study

Análise morfo-histológico sobre prevalência e distribuição de ateroma na aorta abdominal e em seus ramos: estudo em cadáveres

Naveen Kumar; Ashwini P. Aithal; Seemithr Verma

Downloads: 0
Views: 41

Abstract

Abstract: Background: Aneurysms and atheromatous processes are prominent pathological features that are commonly associated with significant morbidity and mortality.

Objectives: This cadaveric study was conducted to evaluate the morphometric and histological aspects of atheromatous plaque formation in abdominal aortas and their branches and their associated morphological variations, if present, characterized by loops, kinking, or tortuosity.

Methods: The study was performed using 30 human cadavers (approx. 65-75 years). Frequency of occurrence of calcified plaques in the abdominal aorta and its branches and their morphometric measurements were noted and histological features were observed with the aid of Hematoxylin & Eosin staining.

Results: Variations in the abdominal aorta and the common iliac artery were observed in 16.6% of specimens. Atheromatous plaque formation was seen in 2 specimens (1 specimen was associated with kinking) while in 3 other specimens only variation in normal structure (kinking/ tortuous artery) was observed. Histological analysis showed foamy macrophages and dense calcification, giving an atheromatous appearance.

Conclusions: Cadaveric reports of the location, nature, and degree of plaque formation in the abdominal aorta and its branches are extremely important in clinical settings and for choosing treatment options.

Keywords

abdominal aorta, iliac artery, atheroma, plaque, stenosis

Resumo

Resumo: Contexto: Aneurismas e processos ateromatosos são características patológicas perceptíveis que costumam estar associadas a morbidade e mortalidade significativas.

Objetivos: Este estudo em cadáveres teve como objetivo avaliar os aspectos morfométricos e histológicos da formação de placa ateromatosa na aorta abdominal e em seus ramos com suas subsequentes variações morfológicas caracterizadas por enrolamentos, acotovelamentos ou tortuosidades, se presentes.

Métodos: O estudo foi realizado com 30 cadáveres humanos (aproximadamente 65-75 anos). Foi descrita a frequência de ocorrência de placas calcificadas na aorta abdominal e em seus ramos com as respectivas medidas morfométricas e características histológicas com auxílio da coloração por hematoxilina e eosina.

Resultados: Variações na aorta abdominal e na artéria ilíaca comum foram observadas em 16,6% dos espécimes. A formação de placa ateromatosa foi observada em dois espécimes (um espécime foi associado a acotovelamento), enquanto em outros três espécimes houve apenas variação na estrutura normal (acotovelamento/artéria tortuosa). A análise histológica mostrou macrófagos espumosos e calcificação densa, o que gerou uma impressão ateromatosa.

Conclusões: Os estudos em cadáveres sobre localização, natureza e grau de formação de placa na aorta abdominal e em seus ramos são extremamente importantes para os cenários clínicos e as opções de tratamento.
 

Palavras-chave

aorta abdominal, artéria ilíaca, ateroma, placa, estenose

References

1 Standring S. Gray’s anatomy. 39th ed. London: Churchill Livingstone/Elsevier; 2005.

2 Virmani R, Burke AP. Nonatherosclerotic diseases of the aorta and miscellaneous diseases of the mains pulmonary arteries and larges veins. In: Silver MD, Gotlieb AI, Schoen FJ, editors. Cardiovascular pathology. New York: Churchill Livingstone; 2001. p. 107-37.

3 Jacob AD, Barkley PL, Broadbent KC, Huynh TT. Abdominal aortic aneurysm screening. Semin Roentgenol. 2015;50(2):118-26. http://dx.doi.org/10.1053/j.ro.2014.10.003. PMid:25770342.

4 Pande RL, Beckman JA. Abdominal aortic aneurysm: populations at risk and how to screen. J Vasc Interv Radiol. 2008;19(6, Suppl):S2-8. http://dx.doi.org/10.1016/j.jvir.2008.03.010. PMid:18502382.

5 Kumar Y, Hooda K, Li S, Goyal P, Gupta N, Adeb M. Abdominal aortic aneurysm: pictorial review of common appearances and complications. Ann Transl Med. 2017;5(12):256. http://dx.doi.org/10.21037/atm.2017.04.32. PMid:28706924.

6 Glagov S, Zarins C, Giddens DP, Ku DN. Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries. Arch Pathol Lab Med. 1988;112(10):1018-31. PMid:3052352.

7 Strong JP. Atherosclerotic lesions: natural history, risk factors, and topography. Arch Pathol Lab Med. 1992;116(12):1268-75. PMid:1456871.

8 Thubrikar MJ, Robicsek F. Pressure-induced arterial wall stress and atherosclerosis. Ann Thorac Surg. 1995;59(6):1594-603. http://dx.doi.org/10.1016/0003-4975(94)01037-D. PMid:7771858.

9 Brubaker PH, Kaminsky L, Whaley M. Coronary artery disease: essentials of prevention and rehabilitation programs. Champaign, IL: Human Kinetics; 2002.

10 Zarins CK, Giddens DP, Bharadvaj BK, Sottiurai VS, Mabon RF, Glagov S. Carotid bifurcation atherosclerosis. Quantitative correlation of plaque localization with flow velocity profiles and wall shear stress. Circ Res. 1983;53(4):502-14. http://dx.doi.org/10.1161/01.RES.53.4.502. PMid:6627609.

11 Gijsen FJ, Wentzel JJ, Thury A, et al. A new imaging technique to study 3-D plaque and shear stress distribution in human coronary artery bifurcations in vivo. J Biomech. 2007;40(11):2349-57. http://dx.doi.org/10.1016/j.jbiomech.2006.12.007. PMid:17335832.

12 Günenç Beşer C, Karcaaltıncaba M, Çelik HH, Başar R. The prevalence and distribution of the atherosclerotic plaques in the abdominal aorta and its branches. Folia Morphol. 2016;75(3):364-75. http://dx.doi.org/10.5603/FM.a2016.0005. PMid:26821603.

13 Stary HC, Chandler AB, Dinsmore RE, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1995;92(5):1355-74. http://dx.doi.org/10.1161/01.CIR.92.5.1355. PMid:7648691.

14 Ozgur Z, Celik S, Govsa F, Aktug H, Ozgur T. A study of the course of the internal carotid artery in the parapharyngeal space and its clinical importance. Eur Arch Otorhinolaryngol. 2007;264(12):1483-9. http://dx.doi.org/10.1007/s00405-007-0398-6. PMid:17638001.

15 Singh R, Tubbs RS. Histological verification of atherosclerosis due to bends and bifurcations in carotid arteries predicted by hemodynamic model. J Vasc Bras. 2018;17(4):280-9. http://dx.doi.org/10.1590/1677-5449.004118. PMid:30787945.

16 Boonruangsri P, Suwannapong B, Rattanasuwan S, Iamsaard S. Aneurysm, tortuosity, and kinking of abdominal aorta and iliac arteries in Thai cadavers. Int J Morphol. 2015;33(1):73-6. http://dx.doi.org/10.4067/S0717-95022015000100012.

17 Purnendu R, Champak Kumar D, Asutosh P, et al. Kinking, aneurysm and tortuosity of common iliac arteries in two cadaver. Indian J Basic Appl Med Res. 2016;5(3):613-8.

18 Patek PR, De Mignard VA, Bernick S. Changes in structures of coronary arteries susceptibility to atherosclerosis in old rats. Arch Pathol. 1968;85(4):388-96. PMid:4171108.

19 Vanek VW. Combining abdominal aortic aneurysmectomy with gastrointestinal or biliary surgery. Am Surg. 1988;54(5):290-6. PMid:3364867.

20 Tuncer E, Onsel Turk U, Alioglu E. Giant saccular aneurysm of the left main coronary artery. J Geriatr Cardiol. 2013;10(1):110-2. PMid:23610581.

21 Xu C, Zarins CK, Glagov S. Aneurysmal and occlusive atherosclerosis of the human abdominal aorta. J Vasc Surg. 2001;33(1):91-6. http://dx.doi.org/10.1067/mva.2001.109744. PMid:11137928.

22 Janzen J, Berger W, Muss W, Grabik M, Lützenberg R. Abdominal aortometry in 85 cases. Perfusion. 2010;23:110-2.
 


Submitted date:
01/19/2021

Accepted date:
02/21/2021

60ddc5b2a953952b04439284 jvb Articles
Links & Downloads

J Vasc Bras

Share this page
Page Sections