Jornal Vascular Brasileiro
https://www.jvascbras.org/article/doi/10.1590/S1677-54492008000300011
Jornal Vascular Brasileiro
Review Article

Linfangiogênese e genética dos linfedemas: revisão da literatura

Lymphangiogenesis and genetics in lymphedemas: a review of the literature

Mauro Andrade

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Resumo

O estudo do genoma humano propiciou recentes descobertas de genes e de complexos mecanismos de controle da linfangiogênese. Neste artigo esses conhecimentos são revistos, com suas implicações na embriogênese e desenvolvimento do sistema linfático e na etiopatogenia de diferentes formas e síndromes de linfedema hereditário. Algumas doenças linfáticas de transmissão genética e síndromes de aneuploidia são descritas nas suas características genotípicas e fenotípicas. Os avanços na compreensão do crescimento e desenvolvimento dos vasos linfáticos devem trazer novas alternativas terapêuticas nas linfangiodisplasias e no controle da disseminação linfática dos tumores.

Palavras-chave

Linfedema, genética, linfangiogênese

Abstract

Recent advances in the exploration and manipulation of the human genome provided new insights into the intricate genetics and control of lymphangiogenesis. Implications for embryogenesis and development of the lymphatic system and its role in some familial and aneuploid syndromes are reviewed, along with their genotypic and phenotypic characteristics. Increased understanding of growth and development of the lymphatic vessels may bring new therapeutic options for lymphatic angiodysplasias and control of the lymphatic spread of tumors.

Keywords

Lymphedema, genetics, lymphangiogenesis

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