Jornal Vascular Brasileiro
https://www.jvascbras.org/article/doi/10.1590/S1677-54492009005000014
Jornal Vascular Brasileiro
Case report

Heparin-induced thrombocytopenia and endovascular procedures: report of two cases

Christiane Campolina Furquim Werneck; Allan Lossing; Thomas F. Lindsay

Downloads: 0
Views: 858

Abstract

Heparin-induced thrombocytopenia (HIT) is a transient disorder caused by platelet-activating antibodies against platelet factor 4 (PF4)-heparin complexes. Clinically it translates into arterial or venous thrombosis and carries high morbidity and mortality. The use of large doses of heparin during endovascular repair of abdominal aortic aneurysm could increase the incidence of HIT. We report two cases associating the use of heparin during endovascular repair of abdominal aortic aneurysm with the development of HIT.

Keywords

heparin, heparin-induced thrombocytopenia, endovascular repair, abdominal aortic aneurysm

References

Warkentin TE. Heparin-induced thrombocytopenia: diagnosis and management. Circulation. 2004;110:e454-8.

Bartholomew JR. The incidence and clinical features of heparin-induced thrombocytopenia. Semin Hematol. 2005;42:S3-8.

Shuster TA, Silliman WR, Coats RD. Heparin-induced thrombocytopenia: twenty-nine years later. J Vasc Surg. 2003;38:1316-22.

Warkentin TE, Kelton JG. A 14-year study of heparin-induced thrombocytopenia. Am J Med. 1996;101:502-7.

Warkentin TE, Chong BH, Greinacher A. Heparin-induced thrombocytopenia: towards consensus. Thromb Haemost. 1998;79:1-7.

Hirsh J, Heddle N, Kelton JG. Treatment of heparin-induced thrombocytopenia: a critical review. Arch Intern Med. 2004;164:361-9.

Keeling D, Davidson S, Watson H. Haemostasis and Thrombosis Task Force of the British Committee for Standards in Haematology. The management of heparin-induced thrombocytopenia. Br J Haematol. 2006;133:259-69.

Warkentin TE, Greinacher A. Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(^s3 Suppl):311S-37S.

Warkentin TE, Greinacher A, Koster A, Lincoff AM. Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(^s6 Suppl):340S-80S.

Alberio L. Heparin-induced thrombocytopenia: some working hypotheses on pathogenesis, diagnostic strategies and treatment. Curr Opin Hematol. 2008;15:456-64.

Chuter TA, Pak LK, Gordon RL, Reilly LM, Messina LM. Heparin-induced thrombocytopenia and graft thrombosis following endovascular aneurysm repair. J Endovasc Ther. 2003;10:1087-90.

Sociedade Brasileira de Angiologia e Cirurgia Vascular (SBACV)"> Sociedade Brasileira de Angiologia e Cirurgia Vascular (SBACV)">
5ddfbf5d0e8825af684ce1d5 jvb Articles
Links & Downloads

J Vasc Bras

Share this page
Page Sections