Jornal Vascular Brasileiro
https://www.jvascbras.org/article/doi/10.1590/S1677-54492010000400004
Jornal Vascular Brasileiro
Original Article

Prevalência de marcadores de trombofilia em pacientes portadores da síndrome de May-Thurner e trombose de veia ilíaca comum esquerda

Prevalence of thrombophilia factors in patients with May-Thurner syndrome and left common iliac vein thrombosis

Marcos Arêas Marques; Paulo Roberto Mattos da Silveira; Arno von Ristow; Marcus Gress; Bernardo Massière; Alberto Vescovi; José Mussa Cury Filho; Rafael Dias Vieira

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Resumo

CONTEXTO: A relação entre trombose venosa profunda e trombofilia tem sido pouco estudada em indivíduos portadores de compressão da veia ilíaca comum esquerda, conhecida clinicamente como síndrome de May-Thurner. OBJETIVO: Avaliar a prevalência de marcadores de trombofilia nos pacientes portadores de síndrome de May-Thurner e trombose de veia ilíaca comum esquerda. MÉTODOS: Entre março de 1999 e dezembro de 2008, 20 pacientes com síndrome de May-Thurner e trombose de veia ilíaca comum esquerda foram avaliados retrospectivamente quanto à presença de marcadores de trombofilia. RESULTADOS: Foi detectada a associação entre síndrome de May-Thurner e marcadores de trombofilia em 8 pacientes (40%). CONCLUSÃO: A presença de marcadores de trombofilia em pacientes com trombose de veia ilíaca comum esquerda e síndrome de May-Thurner é frequente, porém não difere da prevalência encontrada em pacientes portadores de trombose venosa profunda sem a síndrome associada.

Palavras-chave

Trombofilia, trombose venosa, fatores de risco

Abstract

BACKGROUND: The relationship between deep venous thrombosis and thrombophilia has been little studied in patients with left common iliac vein compression, clinically known as May-Thurner syndrome. OBJECTIVE: To evaluate the prevalence of thrombophilia markers in patients with May-Thurner syndrome and left common iliac vein thrombosis. METHODS: From March 1999 to December 2008, 20 patients with May-Thurner syndrome and left common iliac vein thrombosis were retrospectively investigated for the presence of thrombophilia markers. RESULTS: The association between May-Thurner syndrome and thrombophilia markers was found in 8 patients (40%). CONCLUSION: There is a high prevalence of thrombophilia markers in patients with May-Thurner syndrome and left common iliac vein thrombosis. The prevalence, however, is not different from that found in patients with deep venous thrombosis without May-Thurner syndrome.

Keywords

Thrombophilia, venous thrombosis, risk factors

References

May R, Thurner J. Ein Gefäbsporn in der vena iliaca comunis sinistra als ursache der überwiegend linksseitigen beckenven-thrombosen. Zeitschrift Für Kreislauf-Forschung. 1956;45:912-922.

Cockett FB, Thomas ML. The iliac compression syndrome. Br J Surg.. 1965;52:816-21.

Kibbe MR, Ujiki M, Goodwin AL, Eskandari M, Yao J, Matsumura J. Iliac vein compression in an asymptomatic patient population. J Vasc Surg.. 2004;39:937-43.

Sandri JL. Síndrome de May-Thurner - Tratamento Endovascular. Cirurgia Vascular. :1653-64.

Wolpert LM, Rahmani O, Stein B, Gallagher JJ, Drezner AD. Magnetic resonance venography in the diagnosis and management of May-Thurner syndrome. Vasc Endovascular Surg.. 2002;36:51-7.

Neglén P. Chronic deep venous obstruction: definition, prevalence, diagnosis, management. Phlebology. 2008;23:149-57.

Comerota AJ, Gravett MH. Iliofemoral venous thrombosis. J Vasc Surg.. 2007;46:1065-76.

Douketis JD, Crowther MA, Foster GA, Ginsberg JS. Does the location of thrombosis determine the risk of disease recurrence in patients with proximal deep vein thrombosis?. Am J Med.. 2001;110:515-9.

Grunwald MR, Goldberg MJ, Hofmann LV. Endovascular management of May-Thurner syndrome. Am J Roentgenol.. 2004;183:1523-4.

Bjarnason H. Endovascular treatment for chronic iliofemoral venous obstruction. Perspect Vasc Surg Endovasc Ther.. 2004;16:223-32.

França LHG, Tavares V. Insuficiência venosa crônica: Uma atualização. J Vasc Bras.. 2003;2:318-28.

Heit JA. Thrombophilia: common questions on laboratory assessment and management. Hematology Am Soc Hematol Educ Program.. 2007:127-35.

Paschôa AF. Impacto da pesquisa laboratorial de trombofilia na prevenção secundária e orientação dos doentes com tromboembolismo venoso. J Vasc Bras.. 2006;5:331-2.

Raju S, Neglen P. High prevalence of nonthrombotic iliac vein lesions in chronic venous disease: a permissive role in pathogenicity. J Vasc Surg.. 2006;44:136-43.

Miyakis S, Lockshin MD, Atsumi T. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost.. 2006;4:295-306.

Verhaeghe R. Iliac vein compression as an anatomical cause of thrombophilia: Cockett's syndrome revisited. Thromb Haemost.. 1995;74:1398-401.

May R, Thurner J. The cause of the predominantly sinistral occurrence of thrombosis of the pelvic veins. Angiology. 1957;8:419-27.

Knipp BS, Ferguson E, Williams DM. Factors associated with outcome after interventional treatment of symptomatic iliac vein compression syndrome. J Vasc Surg.. 2007;46:743-49.

Fazel R, Froehlich JB, Williams DM, Saint S, Nallamothu BK. Clinical problem-solving: A sinister development--a 35-year-old woman presented to the emergency department with a 2-day history of progressive swelling and pain in her left leg, without antecedent trauma. N Engl J Med.. 2007;357:53-9.

Ludwig B, Han T, Amundson D. Postthrombotic syndrome complicating a case of May-Thurner syndrome despite endovascular therapy: case report and review. Chest.. 2006;129:1382-6.

Auerbach AD, Sanders GD, Hambleton J. Cost-effectiveness of testing for hypercoagulability and effects on treatment strategies in patients with deep vein thrombosis. Am J Med.. 2004;116:816-28.

Marques MA, da Silveira PRM, Ristow A. Pesquisa de marcadores de trombofilia em eventos trombóticos arteriais e venosos: registro de 6 anos de investigação. J Vasc Bras.. 2009;8:225-31.

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